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Prostate Cancer


Staging

Physician developed and monitored.

Original Date of Publication: 10 Jun 1998
Reviewed by: Stanley J. Swierzewski, III, M.D.
Last Reviewed: 17 Oct 2007

Original Source: http://www.urologychannel.com/prostatecancer/stagingsystems.shtml

Important Facts

  • Prostate cancer staging is based on tumor size, characteristics, and whether it has spread
  • The Jewett-Whitmore system classifies prostate cancer as stage A, B, C, or D
  • Stage A and stage B tumors are confined to the prostate gland
  • The tumor, node, metastasis (TNM) system also may be used to stage prostate cancer

Home » Prostate Cancer » Staging


Staging

The physician "stages" the tumor based on its size, the character of its cells, and the extent of metastasis. Two systems commonly are used for staging prostate cancer: the Jewett-Whitmore system and the TNM (tumor, node, metastases) system.



Jewett-Whitmore system
In the Jewett-Whitmore system, prostate cancer is classified first as stage A, B, C, or D. Stages A and B cancers are considered curable. Stages C and D are treatable, but their prognoses are discouaging. A number is then assigned to describe specific conditions within each stage. For example, a tumor classified as stage B1 is a single cancerous nodule confined to one lobe of the prostate.


Prostate Cancer Stage 1

Click to enlarge the image.

Stage A
Very early and without symptoms; cancer cells confined to the prostate

A1 Well differentiated and slightly abnormal cancer cells

A2Moderately or poorly differentiated and abnormal cancer cells in several locations within the prostate

Prostate Cancer Stage 2

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Stage B
Confined to the prostate, but palpable (detectable by digital rectal exam) and/or detectable by elevated PSA

B0Confined to the prostate, nonpalpable; PSA elevated

B1Single cancerous nodule in one lobe of the prostate

B2Extensive, involvment in one or both prostate lobes

Prostate Cancer Stage 3

Click to enlarge image.

Stage C
Cancer cells found outside the prostate capsule (membrane covering the prostate); spread confined to surrounding tissues and/or seminal vesicles

C1Extends outside the prostate capsule

C2Bladder or urethral obstruction

Prostate Cancer Stage 4

Click to enlarge image.

Stage D
Metastasis (spread) to regional lymph nodes, or to distant bones, organs (e.g., liver, lungs), and/or other tissues

D0 Metastatic, clinically localized, and showing elevated blood PAP levels

D1 Regional lymph nodes involved

D2 Distant lymph nodes, bones, or organs involve

D3 Metastatic disease after treatment

TNM System
The TNM (tumor, node, metastases) system stages are similar to those of the Jewett-Whitmore system, but with more specific alphanumeric subcategories.

Primary tumor (T)

TX Tumor cannot be assessed
T0 No evidence of primary tumor
T1 Clinically not palpable or visible by imaging
T1a Found incidental to other surgery; present in 5% or less of tissue
T1b Found incidental to other surgery; present in 5% or more of tissue
T1c Identified by needle biopsy
T2 Tumor confined within prostate
T2a Involving half a lobe or less of prostate
T2b Involving half a lobe
T2c Involving both lobes
T3 Tumor extends through prostate capsule
T3a Extends through one lobe
T3b Extends through both lobes
T3c Extends into seminal vesicles
T4 Involves structures other than seminal vesicles
T4a Invades bladder neck, external sphincter, or rectum
T4b Invades muscles and/or pelvic wall


Regional Lymph Nodes (N)

NX Nodes cannot be assessed
N0 No regional node metastasis
N1 Single node metastasis, 2 centimeters (cm) or less at largest point
N2 Single node metastasis, 2 cm to 5 cm at largest point, or multiple nodes, no larger than 5 cm at largest point
N3 Metastasis larger than 5 cm in any node

Distant Metastasis (M)

MX Metastasis cannot be assessed
M0 No distant metastasis
M1 Distant metastasis
M1a Distant lymph node(s) involved
M1b Bone(s) involved
M1c Other site(s) involved

Prostate Cancer, Staging reprinted with permission from urologychannel.com
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